Picked up a 2017 S1000XR last week with 605 miles on it, mint.
I've been riding a 2018 1260s Multistrada since 2018 and love it, I would say the suspension is better on the Ducati, more options and more pliant on rough roads, but I have to say the S1000XR is fantastic, love the noise, even on a standard pipe, love the gearbox, the handling is exceptional.
Although it's often labelled as an adventure bike, I have to say that's a bit like putting cargo shorts and fell running shoes on Usain Bolt and calling him a mountaineer!
Have fun out there.